Abstract

AN OVERVIEW: THE NOVEL CARRIER FOR VESICULAR DRUG DELIVERY SYSTEM

Dinesh Chandra*, Kamlesh Km Yadav, Vijay Kumar Singh, Anand Patel,Shashi Chaurasia

Abstract

The focus of this review is to development of a novel drug delivery system. Novel drug delivery system aims to deliver the drug at a rate directed by the needs of the body during the period of treatment, and channel the active entity to the site of action. A number of novel drug delivery system has emerged encompassing various routes of administration, to achieve controlled and targeted drug delivery. Encapsulation of the drug in vesicular structure is one such system, which can be predicted to prolong the existence of the drug in systemic circulation, and reduce the toxicity, if selective uptake can be achieved. Consequently a number of vesicular drug delivery system such as liposomes, niosomes, sphinosomes, transferosomes and pharmacosomes are used to improve the therapeutic index of both existing and new drug molecules by encapsulating an active medicament inside vesicular structure in one such system. The era of vesiclular delivery has much to explore by achieving success in various upcoming systems such as aquasomes, cryptosmes, discomes, emulsomes, enzymosome, genosomes, photosomes, virosomes, vesosomes, proteosomes etc. The approaches like pro vesicular drug delivery, coating of vesicles, layerosomes, ufosomes system etc have also been developed which have better stabilities in comparison to simple vesicular drug delivery systems.

Keywords: Vesicles, lipid based drug delivery systems, liposome, pharmacosome, noisome, transferosome.