Abstract

CHITOSAN BASED MUCOADHESIVE MICROSPHERE: VERSATILE CARRIER FOR NASAL DRUG DELIVERY SYSTEM

Dinesh Chandra*, Shashi Chaurasia, Vijay Kumar Singh, Kamlesh Km Yadav,

Abstract

The nasal route is one of the most permeable and highly vascularised sites for drug administration ensuring rapid absorption and onset of action. The interest in intranasal delivery of drugs as a non‐invasive is increased. In this review we have discussed advantages, disadvantages, mechanism of action and factor affecting the permeability of drugs or biomolecule through nasal mucosa of nasal drug delivery system in local delivery, systematic delivery of the drug. We are also discussed here relevant aspects of biological, physicochemical and pharmaceutical factors of nasal cavity that must be considered during the process of discovery and development of new drugs for nasal delivery as well as in there incorporation into appropriate nasal Pharmaceutical formulations. In recent years, Mucoadhesive microspheres have been developed for oral, buccal, nasal, ocular, rectal and vaginal for either systemic or local effects. The principles underlying the development of Mucoadhesive microsphere and evaluation carried out on these systems are reviewed here.Much has been investigated and much more are to be investigated for the recent advancement of nasal drug delivery system.

Keywords: Nasal route, Permeability,Mucoadhesive Microsphere.