Abstract

FORMULATION AND EVALUATION OF HERBAL GEL FOR ANTIARTHRITIC ACTIVITY

Mohammad Rizwan Ul Haque*, Sakshi R. Yadav, Dr. Dinesh M. Biyani, Dr. G. S. Bhoyar and Dr. Milind J. Umekar

Abstract

The aim of present investigation was to evaluate anti-rheumatic activity of two herbs (Commiphora mukul and Boswellia serrata) and to formulate a topical gel dosage form. Boswellia serrata dry extract 65% was collected from the Konark Herbals and Health Care and Commiphora mukul dry resin was collected from Local Market, Nagpur. The evaluation of crude drug and the re-successive solvent extraction of resin was carried out. Development of gel was done by using carbapol 934 and PEG 400. From the result of preliminary phytochemical screening of extract, it was observed that the fractional product of Commiphora mukul resin contained triterpenoids and sterols. The result obtained from present work indicated that the entire drug was uniformly distributed and there was no precipitation in formulation. It was observed that the formulation was stable at different temperatures and exhibit good percentage spread by weight that would assure the skin application. From the present work, it was concluded that it is possible to formulate the herbal gel for anti-arthritic activity by using Commiphora mukul and Boswellia serrata. The results showed that the content of Gel components had significant effect on their physical, rheological and in vitro drug release characterization.

Keywords: Rheumatoid arthritis, commiphora mukul, boswellia serrata, herbal gel, resins, joint pain.