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WJPR

World Journal of Pharmaceutical Research

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology

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Abstract

SPECTRAL CHARACTERIZATION AND DOCKING STUDY OF NEWLY SYNTHESIZED BENZOTRIAZOLE DERIVATIVES

*Maruthamuthu, Shameela Rajam, Christina Ruby Stella,

Abstract

Some novel benzotriazole derivativeswere synthesized and their interaction with proteins was studied through docking. The reaction of o-phenylenediamine with sodium nitrite, yield benzotriazole. The title compounds were synthesized by treating benzotriazole with CH3COCl, C6H5COCl, C6H5Cl,C6H5NH2Cl and C6H5NH2Cl. Their structures were confirmed by IR 1H-NMR and 13C-NMR. Docking study was done and the compounds Aand C were found to fit well with the target protein COX-1.

Keywords: Benzotriazole, O-phenylenediamine, Docking COX-1

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