Abstract

FORMUATION AND EVALUATION OF DRY SUSPENSION OF ORNIDAZOLE AS PARENTERALS

Anisa Sen*, Dr. Arun Patel, Shailendra Patel and Neelesh Dwivedi

Abstract

The main aim of present research study was to promote the novel application of mixed solvency concept in the formulation of dry dosage forms of poorly soluble drug and to minimize the toxic effects of solubilizers by reducing the concentration of individual solubilizer (used for solubility enhancement). In this research work, poorly water soluble drug ornidazole was selected. It was passed through solubility studies by using various physiologically compatible solubilizers to prepare its parenteral preparation (dry powder injection for reconstitution of ornidazole). In the present research work, the procured sample of ornidazole drug undergone by various characterization parameters. The melting range of drug was determined by the open capillary method and it was found to be 86-90º C. UV Spectrophotometric analysis was performed to obtain its maximum peak which was found to be at 320 nm.

Keywords: Ornidazole, Mixed solvency, Soubelizers, Suspension, Dry Powder.