Abstract

EVALUATION OF EFFECT OF ANTIOXIDANT VITAMIN IN PATIENTS OF DIABETIC NEPHROPATHY

Deshmukh Taarique A.*, Dr. Rakesh Kumar Jat and Dr. Rashid Akhtar

Abstract

As diabetes mellitus progresses patients are at risk of developing specific complications, such as neuropathy, retinopathy and nephropathy. Where Diabetic nephropathy is a life-threatening condition associated with diabetes mellitus and is the leading cause of end-stage renal failure for patients in many countries. The study was designed to evaluate the effect of vitamins as an antioxidant in diabetic nephropathy patient. And to evaluate the effect of antioxidants treatment on renal parameters like, microalbuminuria and creatinine along with glycaemic parameter like HbA1c. In a randomized, open controlled clinical trial 40 type 1 and type 2 diabetic patients (29 men and 11 women) aged 30–80 years who have had diabetes for at least 5 years, with renal function of the patients who have been diagnosed to have microalbuminuria. (Urine albumin excretion >30 mg/dl) divided in 2 groups control and vitamin. Where the patients in vitamin group was receiving daily supplement of antioxidant vitamin (400 mg). Observation indicate that after 3 months of supplementation, levels of UAE decreased in, Vitamins group compare to control group (p = 0.001, p = 0.05 respectively). HbA1c decreased in, Vitamins group (p = 0.01). Level of serum creatinine significantly decreased in vitamin group (p = 0.004). Blood sugar level, systolic BP, diastolic BP did not significantly change in any group. The data demonstrate that treatment with vitamins E is significantly lowers UAER, Glycosylated hemoglobin and serum creatinine in diabetic nephropathy patients.

Keywords: Diabetic nephropathy; microalbuminuria; vitamin E; oxidative stress and antioxidants.