Abstract

META-ANALYSIS OF DRUG TREATMENTS FOR PATIENTS WITH OSTEOPOROSIS AND OVERALL MORTALITY RATES

Fatimah Fakhri Almudarhem*, Layla Mohammad Saad Alsultan, Elham Ali Abdullah Alqahtani, Rana Ali Alowa, Marwa Salman Alluqmani, Fatimah Fareed Almodrhim, Athal Kamal Filemban, Hadeel Hidayat Alla Saleh, Feras Fahad Bin Oways, Ahmed Ali Alawi

Abstract

Background & Purpose: Fragility fractures associated with osteoporosis cause significant costs, morbidity, and mortality. between 10 and 20% of people who maintain hip fractures die within 1 year, and extended mortality is also determined after vertebral and other nonvertebral fractures. The Aim of this work is to provide cumulative data about the effect of drug treatments for patients with osteoporosis on overall mortality. Methods: A systematic search was performed of PubMed, Cochrane library Ovid, Scopus & Google scholar to identify Family medicine RCTs, clinical trials, and comparative studies, which studied the outcome of Treatment group versus Placebo group of osteoporosis patients. A meta-analysis was done using fixed and random-effect methods. The main outcome was associations of all drug treatments, particularly bisphosphonate and zoledronate treatments, with overall mortality. Results: A total of 8 studies were identified involving 19169 patients, with 9565 patients in Treatment group, and 9604 patients in Placebo group. Regarding main outcome measure, the fixed-effects model of the meta- analysis study showed non-significant difference in overall mortality rate in Treatment group compared to Placebo group (p > 0.05). Regarding subgroup analysis for each drug treatment, the fixed-effects model of the meta-analysis study showed non-significant difference in overall mortality rate in patients used all types of drug treatments (p > 0.05). Conclusion: To conclude, although no statistical significance, Osteoporosis therapy appears to reduce mortality risk in all patients.

Keywords: Drug treatments, osteoporosis, overall mortality.