Abstract

EFFECT OF VITAMIN D SUPPLEMENTATION ON GLYCEMIC CONTROL IN TYPE 2 DIABETES MELLITUS PATIENTS

Samah Mohammed Aljohani*, Nasser Nafea Alharbi, Hadeel Rajeh Alnashri, Mohammed Abed Bukhari, Rawan Eid Alamri, Rawan Awad S. Alharbi, Ebtehag Faham Alsulami, Ghadah Massad Alharbi, Ahmed Y. O. Abujazar, Abdullah Yahya Alsaghir

Abstract

Background & Purpose: Vitamin D level in plasma has been connected to the occurrence of metabolic syndrome and insulin resistance. The Aim of this work is to provide cumulative data about the effect of vitamin D supplementation on glycemic control in type 2 Diabetes Mellitus (DM) patients. Methods: A systematic search was performed of PubMed, Cochrane library Ovid, Scopus & Google scholar to identify Endocrinology RCTs, clinical trials, and comparative studies, which studied the outcome of Vitamin D group versus Placebo group of DM patients. A meta-analysis was done using fixed and random-effect methods. The primary outcome was the mean change from baseline in serum vitamin D. Secondary outcome was the effects on HbA1c. Results: A total of 5 studies were identified involving 245 patients, with 138 patients in Vitamin D group, and 107 patients in Placebo group. Regarding primary outcome measures, the fixed-effects model of the meta- analysis study showed highly significant increase in mean vitamin D change in Vitamin D supplemented group compared to Placebo group (p = 0.049). Regarding secondary outcome measures, the fixed-effects model of the meta-analysis study showed non-significant difference in vitamin D effects on HbA1c in Vitamin D supplemented group compared to Placebo group (p > 0.05). Conclusion: To conclude, current evidence of RCTs does now not support short-term vitamin D supplementation in a heterogeneous population with type 2 diabetes. however, in patients with poorly controlled diabetes, a favorable effect of vitamin D is seen on fasting glucose.

Keywords: Vitamin D, Glycemic control, DM.