Abstract

NOVEL APPLICATION OF MIXED SOLVENCY CONCEPT IN THE DEVELOPMENT OF FAST DISSOLVING SOLID DISPERSION OF POORLY WATER-SOLUBLE DRUG, TORSEMIDE AND ITS EVALUATIONS

Jaydeep Singh Baghel* and R. K. Maheshwari

Abstract

The aim of the present research work is to explore the application of mixed solvency concept to formulate and develop a fast dissolving solid dispersion. In the present study, poorly soluble drug, torsemide (model drug) was tried to be solubilized by employing the combination of physiologically compatible water soluble additives (solubilizers) to formulate its fast dissolving solid dispersion. Material and Methods: For poorly water soluble drug torsemide, combination of solubilizers such as sodium caprylate, sodium citrate, sodium acetate and beta cyclodextrin as mixed solvent systems were used to decrease the overall concentration of solubilizer required to produce substantial increase in solubility of torsemide. The procured sample of torsemide was characterized by melting point, IR, UV, and DSC studies. Stability studies of solid dispersion of torsemide were performed for two months at room temperature and cool temperature. All the formulation were physically, chemically and microbiologically stable. Conclusion: Mixed solvency concept has been successfully employed for enhancing drug loading of poorly water soluble drug, torsemide.

Keywords: Mixed solvency, hydrotropy, torsemide, solid dispersion, solubility.