Abstract

A REVIEW ON FORMULATION AND EVALUATION OF PULSATILE DRUG DELIVERY SYSTEM

A. Vijaya Madhavi*, D. Rama Brahma Reddy, M. Venugopal, N. Srihari, P. Chennaiah, P. Koteswararao

Abstract

In the current scenario of pharmaceutical research much attention has been focused on patients‟ health in terms of therapeutic efficacy and safety thing in mind. Pulsatile drug delivery system is the most interesting time and site specific system. This system is designed for chronopharmacotherapy which is based on cardiac rhythm. pulsatile drugdelivery system is most intresting time and site specific system as per pathophysiologocal need of the disease. Pulsatile drug delivery system is characterized by time of period of no release(lagtime) fallowed by a rapid and complete drug release. The system are beneficial for the drug having chronopharmacological behavior were night time dosing is required and for the drugs having high first pass effect and having specific site of absorption in gastro intestinal tract. The current article focuses on the review of literature concerning the disease requiring PDDS, Methodologies involved in the existing systems, significance of swelling agent, and recent technologies in PDDS.

Keywords: Pulsatile drug delivery, Swelling agent, Swelling Index, Lag time, Chronotherapy, Capsular System.