Abstract

A REVIEW ON LAMIVUDINE & ABACAVIR IN BULK & PHARMACEUTICAL DOSAGE FORM

Shelke Archana K.*, Dr. N. S. Dighe and Prof. A. S. Dighe

Abstract

A simple and rapid high performance liquid chromatographic method was developed and validated for simultaneous estimation of abacavir and lamivudine in their tablet dosage form. Abacavir is an antiretroviral drug used to treat HIV/AIDS. Lamivudine (2′,3′-dideoxy- 3′-thiacytidine, commonly called 3TC) is a potent nucleoside analog reverse transcriptase inhibitor (nRTI). In the present study focus is laid on this combination drug, the retention times of Lamivudine and Abacavir were found to be 0.9 min and 4.5 min respectively. Hence, the developed method can be successfully employed for routine quality control of Lamivudine and Abacavir in drug testing laboratories and pharmaceutical industries.

Keywords: Antiretroviral agents, Lamivudine, Abacavir, RP-HPLC, HIV.