Abstract

A REVIEW: TRANSDERMAL DRUG DELIVERY SYSTEM FOR VARIOUS NON-STEROIDAL ANTI-INFLAMMATORY DRUGS AS A NOVEL DRUG DELIVERY SYSTEM

Ketan Chandrakant Shinde*, Ashwini Ramdas Sable*, Sayali Uday Budhavant, Sameer Dilip Pawar and Reshma Pawar

Abstract

Transdermal drug delivery has made an important contribution to medical practice, but has yet to fully achieve its potential as an alternative to oral delivery and hypodermic injections. Transdermal drug delivery system (TDDS) provides sustain drug release for systemic as well as local treatment and reduces the side effects associated with its oral therapy. Transdermal drug delivery system has been accepted as potential non-invasive route of drug administration, with advantages of prolonged therapeutic effect, reduced side effects, improved bioavailability, better patient compliance and easy termination of drug therapy. Non-steroidal anti-inflammatory drugs (NSAIDs) represents the most commonly used medications for the treatment of pain and inflammation, but numerous well-described side effects can limit their use. Transdermal delivery of NSAIDs has advantages of avoiding hepatic first pass effect, drug degradation in GIT, specific problems associated with the drug like gastric irritation and lower absorption. By TDDS of NSAIDs can be deliver the drug for extended period of time at a sustained level. The present article gives the brief view on the formulation, development and evaluation been done on various NSAIDs transdermal patches to reduce the side effects associated with the oral delivery.

Keywords: TDDS, Transdermal Patches, Permeation Enhancers.