Abstract

FORMULATION AND CHARACTERIZATION OF TRIGONELLA FOENUM GRAECUM (FENUGREEK) SEED POLYSACCHARIDE NANOPARTICLES USING DILTIAZEM HCl AS MODEL DRUG

Jyothsna Chakrala*

Abstract

The main aim of the present investigation is to optimize and evaluate the fenugreek seed polysaccharide nanoparticles using Diltiazem HCl as a model drug because Diltiazem HCl has short half life and it is BCS class I drug. Nanoparticles were prepared by using desolvation method and evaluated to study the influence of polymer concentration and stirring speed on different characteristics of nanoparticles such as particle size, surface morphology, zeta potential, Encapsulation efficiency and Invitro drug release. FTIR, DSC and XRD studies were also performed to determine the compatibility, degradation and crystalline nature of drug before and after formulation of nanoparticles. F7 (1:2 polymer concentration and 600 stirring speed) was optimized formulation based on its particle size (672.1nm), encapsulation efficiency (83.1) having higher stability of Zeta potential value of -26.2, smooth surface morphology and having higher retarded drug release with non fickkian diffusion. By studying all the characteristics it was finally concluded that a natural polymer obtained from fenugreek seed can be used as a rate controlling polymer in the preparation of nanoparticles.

Keywords: Diltiazem HCl, Fenugreek seed polymer, rate controlling polymer, Nanoparticles, Desolvation.