Abstract

IN-VITRO ANTISPASMODIC EFFICACY OF ETHANOLIC EXTRACT OF LEAVES OF SESBANIA GRANDIFLORA

Akanksha Jagdale*, Dr. Sandeep Patil, Hanmant Mali, Miss. Snehal Chandanshive

Abstract

The aim of this research was to use invitro pharmacological assay to provide the pharmacological basis for Sesbania grandiflora as an antispasmodic agent. It has been used to treat most illnesses in traditional medicine. The present study was undertaken to evaluate invitro antispasmodic activity of ethanolic extract of leaves Sesbania grandiflora by interpolation method on isolated chicken ileum. A kymograph reported the combined response of concentration to atropine and acetylcholine in the absence and presence of ethanolic extract. This revealed Sesbania grandiflora's ethanolic extract blocks the action of acetylcholine preventing impulses from the parasympathetic nervous system from entering smooth muscles and triggering contraction.

Keywords: Antispasmodic Activity, In-vitro assay, Sesbania grandiflora, ethanolic extract.