Abstract

PHARMACOLOGICAL SCREENING OF ETHANOLIC LEAF EXTRACT OF MYXOPYRUM SERRATULUM

R. Santhanalakshmi and *R. Vimalavathini

Abstract

Antiasthmatic activity of ethanolic leaf extract of Myxopyrum serratulum (EEMS) by in-vitro and in vivo methods were carried out. EEMS exhibited anti-histaminic and anti-cholinergic activity in isolated goat tracheal muscle. It also protected egg albumin induced degranulation of mast cells in dose dependant manner. For in vivo studies EEMS significantly inhibited the duration of catalepsy and showed a significant decrease in leukocytes and differential count in dose dependent manner. Thus the present study suggests that EEMS exhibited significant antihistaminic, mast cell stabilizing and antiallergic activity in dose dependent manner. So, it can be utilized for the treatment of asthma and further studies are required to elucidate its exact mechanism of action to support this traditional claim.

Keywords: Antiasthmatic, In vitro. In vivo.