Abstract

HAVE GLYCYRRHIZA GLABRA & COLCHICINE CYTOTOXIC EFFECT ON PATIENTS WITH CHRONIC MYELOGENOUS LEUKEMIA

Faruk H. Al- Jawad, Nahi Y. Yaseen, Haitham M. Kadhim* and Inssaf I. Hussein

Abstract

Background: Chronic myelogenous leukemia is a malignant clonal, myeloproliferative disorder of the pluripotent hematopoietic stem cells. the objective to evaluate in vitro the cytotoxic effect of both glycyrrhiza globra (licorice) and colchicne on normal myeloid stem cell & leukemic myeloid cells of patients with chronic myelogenous leukemia. The serial dilution of aqueous licorice extraction & colchine in the concentration (250,125,68.5,31.25,15.625,7.8,25 μg/ml) were added to the cell culture. Cells viability was assessed by MTT assay. Results: The obtained results shamed that the toxic effect (inhibitory rate of growth) of both licorice & colchicines urea in dose e and time dependent. There were significant difference (P

Keywords: Glycyrrhiza globra-licorice, colchicine, normal & leukemic myeloid cells culture.