Abstract

PROTECTIVE EFFECTS OF AEGLE MARMELOS IN LEAD INDUCED GENOTOXICITY IN BONE MARROW CELLS OF MICE.

K.Rudrama Devi, Ch.Prabhakar Reddy and J.Karuna Kumari.

Abstract

In the present studies, the protective effects of Aegles marmelos fruit extract has been evaluated against Lead nitrate induced micronuclei in bone marrow cells of mice. Single I.P treatement of Aegles marmelos fruit extract of various test doses 200, 400 & 600 mg/kg had shown non toxic nature in bone marrow cells of mice. In Lead nitrate treated groups, there is a significant increase in the frequency of micronuclei in polychromatic erythrocytes of mice when compared with control values. However, along with Lead nitrate when animals were primed with Aegles marmelos fruit extract there is an inhibition in the frequency of micronuclei was observed at all dose levels. Thus that clearly indicate protective effects of Aegles marmelos fruit extract against Lead nitrate induced genotoxicity in bone marrow cells of mice. Therefore the data showed Aegles marmelos fruit extract is a safer dietary component in heavy metal induced DNA damage in cancer chemotherapeutic strategy.

Keywords: Aegles marmelos fruit extract, Micronuclei,Bone marrow cells.