Abstract

FORMULATION AND IN-VITRO EVALUATION OF MUCOADHESIVE BUCCAL PATCHES OF FUROSEMIDE

Km. Pratiksha*, Dr. Vikas Sharma, Lavkush Tiwari and Kris Jain

Abstract

This study is mainly focused on the ability of polymer to polymer to expand the bioavailability of Furosemide and to release the drug in controlled foreordained way. The polymers selected for the study include natural and synthetic polymer like Poly vinyl alcohol, Poly vinyl pyrolidine, Propylene glycol and HPMC 15 based on their physicochemical properties. The mucoadhesive buccal patches were prepared by solvent casting method. The prepared patches were subjected to physical evaluations, in vitro diffusion studies and stability study. All the formulations have shown good adhesive property, tensile strength, folding endurance, thickness, pH and moisture content. The diffusion studies have shown that the percentage drug release is from natural polymer based patches is more than the synthetic polymer with different polymer based mucoadhesive patches. The In vitro drug release, evaluation, stability and accelerated stability studies of the mucoadhesive patches shown that the formulation containing natural polymer has the promising results with 100.71% drug release within 10 hours, folding endurance 301-319, patch thickness 0.21-0.27 mm, surface pH 6.16-6.70, moisture content 1.73 to 2.91, tensile strength 5.18 to 13.64 kg/mm2.

Keywords: Furosemide, Buccal patches, Mucoadhesive, In-vitro drug release.