Abstract

ANTI-INFLAMATORY ACTIVITY OF ACACIA NILOTICA PODS EXTRACTS IN EXPERIMENTAL RATS

S. K. Sarje*, Swati Tekale, Thakur Adhika, Tiwari Nikita and Yengload Sharda

Abstract

Inflammation is body’s response to disturbed homeostasis occurs mainly due to infection, injury or trauma resulting in systemic and local effects. The Roman writer Celsus in1st Century AD named the four Cardinal Signs of inflammation as Rubor (redness), Tumor (swelling), Calor (heat) and Dolor (pain). Acacia nilotica has long been used in folk medicine in treatment of diarrhoea, snake bite, malaria, smallpox, fever, scabies; ulcer, and stomach disorders. [Prajapti et al 2003]. Although a lot of work has been done on the pharmacological activities and phytoconstituents isolation of seed and leaves of A. nilotica but no work has been done on anti-inflammatory activity of pods extract of A. nilotica. Therefore, the aim of the present work is ―Evaluation of antiinflammatory activity of pods extracts of Acacia nilotica.‖ The work was initiated with authentication of plant Acacia nilotica. Morphological, Acute toxicity study aims at establishing the therapeutic index. Extracts were found safe up to 2000 mg/kg. In-vitro and in-vivo anti-inflammatory activity of ethyl acetate, ethanolic extract of Acacia nilotica was evaluated by using hyaluronidase inhibition assay and the carrageenan induced paw edema models.

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