Abstract

EVALUATION OF ANTIMICROBIAL ACTIVITY OF CRUDE FLAVONOIDS IN MEDICINALLY IMPORTANT ARID ZONE PLANTCLERODENDRUM PHLOMIDIS LINN.

Jasvinder Kaur Chahal and Renu Sarin*

Abstract

Medicinal plants are source of many valuable drugs and the isolation, identification, purification and characterization of bioactive compounds of these plants are beneficial for healthy living of human beings. Several wild plants and herbs species used traditionally in medicinal field as rich source of medicine. This article is based on the evaluation of the crude flavonoid (free and bound) of Clerodendrum phlomidis against some pathogen. The benzene extracts of plants parts and callus culture (leaves, root and calli) were found to be effective against Gram positive bacteria - Bacillus subtilis (ATCC 6633) (B.s.), Staphylococcus aureus (ATCC 25923) (S.a.) Gram negative bacteria - Escherichia coli (ATCC 25922) (E.c.), Psedomaonas aeruginosa (ATCC 27853) (P.a.) and fungal strains Aspergillus niger (ATCC 16404) (A.n.), Aspergillus flavus (ATCC 9807) (A.f.), Candida albicans (ATCC 5027) (C.a.) and Candida glabrata (ATCC 66032) (C.g.). However, aqueous extracts of C. phlomidis did not show any inhibitory effect against tested pathogenic fungal and bacterial strains. This investigation concluded that the flavonoids extracts of C. phlomidis are effective for both antifungal and antibacterial activities.

Keywords: Clerodendrum phlomidis, flavonoids, Antimicrobial activity, Inhibition zone, Minimum inhibitory concentration.