Abstract

PREVALENCE OF ADVERSE DRUG REACTIONS IN INDIA –SYSTEMIC ANALYSIS

Priyanka Jamalapurapu*, Lavanya Kancharla, Dhanush Bellapu and Padmalatha Kantamneni

Abstract

Nowadays Adverse drug reactions related admissions have significantly increased over past few decades. Antibiotics are most widely misused drugs in developing countries in the form of over the counter use, self medication and irrational prescriptions. ADR was the fourth to sixth most cause of death in India. The objective of this study was to make an overall view on different ADR studies about the incidence and prevalence of ADR in inpatients of various hospitals and also to find out the mortality, causality and most common drugs causing ADRs. 15 articles were taken into consideration for our study from the year 2008-2019 which were obtained from Google Scholar; Medline, Embase and Pubmed from 2008 –2019. A total of 65 articles were found based on the keyword adverse drug related hospital admission. Abstract –only articles, out –patient ADR studies were filtered. Finally 15 articles were taken into consideration for our study. Based on these articles systemic analysis was made and results were outlined. Higher prevalence of ADRs was observed in anti –microbials followed by anti –tubercular and anti –neoplastics. In anti – microbials class cephalosporins and beta-lactams have shown higher incidence of ADRs. For safety and rational use of antimicrobials, implementation of antimicrobial guideline policy and strict adherence to it should be established.

Keywords: Adverse drug reactions, Pharmacovigilance, Anti microbials.