Abstract

SYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL ACTIVITY OF SOME METAL COMPLEXES DERIVED FROM THIAZOLE SCHIFF BASE (2-THIOPHENE CARBOXAMIDE-2, 6- DIAMINOPYRIDINE)

Dr. MD. Fakruddin Ali Ahammed*, A.C.V. Neeraja, D. Glory, D. Subhashini, B. Ameena and P. Reddy Aupraja

Abstract

As multidrug resistant pathogens are emerging, the search for novel potent drug candidates is ever going. Heterocycles are known by their broad spectrum of biological activities, so a search for a new drug from heterocycles can elevate the chance of success. The aim of this study was to obtain novel potent antimicrobial compounds. In line with this 2-Thiophene Carboxamide-2,6-DiaminoPyridine and its complexes (Cu(II), Co(II) Zn(II), Pb(II) and Hg(II)) were synthesized, characterized, and evaluated against bacterial strains. The compounds were characterized by elemental analyses (C, H, N, and S), FT-IR, 1HNMR, 13C-NMR, UV-Vis spectra, and molar conductivity measurement. The results showed that the ligand is tetradendate, and the molar conductivity measurement indicates that complexes are electrolytic. Electronic spectral study showed octahedral and distorted octahedral geometry for the (Cu (II), Co (II) Zn (II), Pb (II) and Hg (II)) complex, respectively. The ligand and its complexes were screened against four bacterial strains using disk diffusion method. The result revealed that the Hg (II) complex showed more bioactivity than gentamicin against Staphylococcus aureus and Escherichia coli, while the Cu (II) complex is more active than the Zn (II) complex against Bacillus subtilis. Both (Cu (II), Co (II) Zn (II), Pb (II) and Hg (II)) complexes exhibit higher antibacterial activities than the free ligand.

Keywords: Schiff base, antimicrobial activity, 2-Thiophene Carboxamide-2, 6 Diamino Pyridine, Metal complexes.