Abstract

FORMULATION AND EVALUATION OF COLON DRUG DELIVERY OF METRONIDAZOLE MINI-TABLETS

Pavani S.*, Shravan Kumar Y. and Nagaramya C. H.

Abstract

The objective of the current study was to develop and optimize a Metronidazole mini-tablets colon specific drug delivery formulation which is an effective drug in the treatment of amoebiasis. In this minitablets were prepared by direct compression method and coated with pH sensitive polymers Eudragit S-100, Eudragit L-100 and combination of Eudragit S-100 & L-100 in different ratios. The optimized tablet formulation i.e., F5 is coated with 12% of Eudragit S- 100 & L-100. The drug release studies were performed using 0.1 N HCl for 2 h, followed by phosphate buffer pH 6.8 for 3 h and finally in phosphate buffer pH 7.4. F5 shows the best in-vitro drug release of about 97.32% within 24 h in 7.4 pH buffer whereas with pectinase enzyme the drug release was found to be 99.70% within 12 h, following Korsemeyer-peppas and non-fickian diffusion (n=0.67).

Keywords: Amoebiasis, Eudragit S-100 Eudragit L-100, Pectin, Pectinase.