Abstract

PHYSICO-CHEMICAL STANDARDIZATION OF THE DRUG “NANDUKKAL BHASHMAM”

Dr. P. V. Thillany*, Dr. K. Kugarani, Dr. N. Puvitha, Dr. N. Suganya, Dr. R. Thatparan and Dr. K. Velauthamoorthy

Abstract

The drugs used in Siddha Medicine is classified as internal and external medicines each consisting of 32. One efficacious nano medicine that is used in “Kalladaippu” (Urolithiasis) is “Nandukkal Bhashmam” which denotes the “bhashmam” class drug in internal medicines. The main objective of the study is to standardize the drug “Nandukkal Bhashmam” through physico-chemical analysis. As per to that “Nandukkal Bhashmam” was prepared and the physico-chemical analysis was carried out including traditional “Bhashmam pareekshai” (bhashmam examinations). According to the results obtained the organoleptic characteristics of “Nandukkal Bhashmam” was solid in nature, grey color in daylight and the smell, sound and taste were not to be found characteristic. The drug sample fulfilled important bhasmam pareekshai(Examination of bhashmam) as Nischandratvam, Rekhapurnatvam, Varitaratvam and Amila pareekshai. It was observed that, 0.4328%, a negligiable loss on drying, 99.8249% of high total ash value, 0.99% water soluble ash value and 82.26% acid soluble ash value. pH of the drug with deionized water is 7.91 (28.3oC), 7.20 (29.5 oC) with dry Aerva lanata decoction and 7.04 (29.5 oC) with fresh Aerva lanata decoction. The water soluble extractive value of the drug “Nandukkal Bhashmam” is 0.88%, alcohol soluble extractive value of the formulation is, 0.704%, and no significant value was observed in ether soluble extractive. The bottomline of the study is that, the analysis of physico-chemical characteristics of Nandukkal Bhashmam indicates the consequence of drug standardization before introduce into the market. Further studies should be executed to increase the safety and efficacy of the drug Nandukkal Bhashmam through sophisticated analytical instruments.

Keywords: Nandukkal Bhashmam, Physico-chemical analysis, Kalladaippu.