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WJPR

World Journal of Pharmaceutical Research

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology

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Abstract

ANALGESIC ACTIVITY OF THIOSEMICARBAZONE & THIAZOLYL HYDRAZONE SCHIFF BASES OF 1-INDANONE

Urooj Nazim*, Mansoor Ahmed, Ghazala Ishrat, Amir Hassan, Shazia Haider, Sohail Hassan

Abstract

Thiosemicarbazone and a series of Thiozolyl hydrazone of 1-indanone have been synthesized. Analgesic activity of the prepared derivatives was evaluated in vitro in comparison to standard drug (Aspirin) by tail flick method. Out of 13 synthesized compounds (c1- c13) 9 showed analgesic activity and 4 compounds (c3, c6, c11 and c13) were found inactive. Out of 9 active compounds 3 compounds (c7, c8 and c12) were found comparable with Aspirin from 30-90min. None of the compound was found more active than Aspirin.

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