Abstract

A REVIEW ON FORMULATION AND EVALUATION OF COLONAL PATCHES

*Botla Sirisha, Rayidi Priyanka and Dr. K. Abbulu

Abstract

The main aim of this study was to Formulate and evaluate colonal patches based colon targeted systems of Abiraterone acetate using different Mucoadhesive polymers such as carbopol934P, HPMC K100M, NaCMC containing the drug Abiraterone acetate were prepared using solvent casting method. The polymers like ethyl cellulose, Hpmck100m, xanthum gum in different combinations for effective delivery of drug to the colon. The prepared hydrogel plug with this polymer was plugged to the capsule body containing the formaldehyde coating The formaldehyde coated capsules were prepared to decrease the solubility of gelatin where cross linking of the amino group in gelatin group with aldehyde group. In vitro drug release studies were performed in 0.1N HCl for 2 h followed by in pH 6.8 phosphate buffer for 3 h, finally in pH 7.4 phosphate buffer for 6-12 h. The dissolution data demonstrated that the rate of drug release decreased by the formaldehyde treatment and hydrogel plug till the delivery of the drug to the colon. The colonal patches were studied for various physic chemical properties. The weight uniformity is 242.00±1.0 to 250.30±1.60mg. The thickness is 0.43±0.031 to 0.49±0.037mm. The folding endurance is 163±2.0 to 195±4.0sec. The surface pH is 6.2±0.15 to 7.4±0.30.The swelling index is 70.12 to 81.71٪. The Mucoadhesive strength is 204±29.53 to 251±24.61.The Mucoadhesive time is 204±29.53 to 250±24.27. The drug content is 90.21 to 99.96٪. The moisture uptake and moisture content is 0.3±0.01 to 1.68±0.02 and 0.32±2 to 0.54±4. The release was sustained in colonal patches prepared with carbopol and sodium alginate. capsule were evaluated and confirmed that 8 hrs formaldehyde treatment was sufficient.100mg hydrogel plug was optimized Hardness and thickness of the plug controlled lag time.

Keywords: Pulsatile drug delivery system, Hydrogel plug, Formaldehyde treatment, colonal drug delivery.