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WJPR

World Journal of Pharmaceutical Research

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology

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ICV : 90.8

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Abstract

SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL EVALUATION OF SOME NOVEL CARBOXAMIDE DERIVATIVES OF PYRAZOLE

Abhishek Arvadiya*, Dr. Bony Patel, Dr. Khyati Patel and Mayursinh Zala

Abstract

A series of 1-(6-(benzylamino)pyrimidin-4-yl)-5-methyl-1Hpyrazole- 4-carboxamides derivatives have been synthesised by using different acids. All steps were synthesised by green procedure with excellent yield. Product obtained were characterised by means of the NMR, IR and Mass spectral analysis. The synthesized compounds were evaluated for their in-vitro antimicrobial activity against different bacterial and fungal strains using Mueller- Hinton Broth dilution method and also invitro antitubercular activity was performed.

Keywords: pyrimidin, pyrazole, carboxamides derivatives, biological activities.

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