Abstract

OXIDATION REDUCTION REACTIONS BY CANDIDA PARAPSILOSIS

Vidya S. Kukde* and Mrunali A. Bhongade

Abstract

Candida parapsilosis is an emerging major human pathogen that is dramatically increased in significance and prevalence over the past 2 decades, such that C. parapsilosis is now one of the leading causes of invasive candidal disease. The yeast, Candida sp. is used to syntheses of a broad range of chiral compounds as whole cells and isolated enzymes. Candida sp. is also the important source of oxidoreductases. The important biocatalytic reactions mediated by C. parapsilosis such as deracemization, asymmetric reduction of prochiral ketones, imines, resolution of racemic alcohols through selective oxidation. The present review shows the importance of the C.parapsilosisas a versatile biocatalyst for the organic oxidation reduction reaction. It presents the importance of whole cell of C. parapsilosis which catalysed the many reactions. It gives deracemization reactions for so many sec. alcohols, aliphatic and aromatic diols, aryl ethanol, etc. It also presents the immobilised whole cells of C. parapilosis as a biocatalyst for many reactions. By using the whole cells of C. parapsilosis, optimization and scale up biocatalysis can be carried out.

Keywords: Candida parapsilosis, Oxidation, Reduction, Biocatalyst, Asymmetric reduction.