Abstract

PROTECTIVE ROLE OF MEDICINAL PLANTS ON NICOTINEINDUCED TISSUE TOXICITY

Amit Nandi, Soumita Dey, Sandip Kumar Sinha and Sankar Kumar Dey*

Abstract

Nicotine is most frequently encountered in tobacco products for smoking, chewing, sniffing and tobacco "without smoking". Nicotine is one of the most toxic of all poisons and has a rapid onset of action. Apart from local caustic actions, the target organs are the peripheral and central nervous systems. Nicotine is also a powerfully addictive drug. Burning sensation in the mouth and throat, salivation, nausea, abdominal pain, vomiting and diarrhoea. Gastrointestinal reactions are less severe but can occur even after cutaneous and respiratory exposure. A transient increase in blood pressure, followed by hypertension, bradycardia, paroxysmal atrial fibrillation, or cardiac standstill may be observed. In severe poisoning, tremor, convulsions and coma occur. Faintness, prostration, cyanosis and dyspnoea progress to collapse. Death may occur from paralysis of respiratory muscles and/or central respiratory failure. Medical plants play an important role in the management of different diseases. Based on these evidences, the current review was performed the effect of nicotine induced tissue toxicity and to clarify the ameliorative effect of different medicinal plants.

Keywords: Nicotine, Lungs, Heart, Liver, Kidney, Medical Plants.