Abstract

DEVELOPMENT AND IN-VITRO EVALUATION OF CHLORHEXIDINE AND FLURBIPROFEN COMPRESSED TABLET LOZENGES

Midhun Kumar Duddu*, P. Renuka, Y. Madhusudhan Rao, Sandesh and Adella Aparna

Abstract

The mouth of human body provides non-shedding surfaces (teeth) for natural microbial colonization. This can result in the accumulation of large masses of bacteria and their products at stagnant sites. Dental plaque, Periodontitis and gingivitis are some of this type of conditions, which can develop due to microbial accumulation on teeth and Infections of throat leading to tonsillitis, pharyngitis, laryngitis, sour throat etc. Chlorhexidine is widely used antimicrobial drug in the treatment of dental plaque and gingivitis and Flurbiprofen is used as anti-inflammatory drug to reduce pain and inflammation. Lozenges are designed to deliver medications directly to the mucus membranes of the mouth and oropharengial cavity by dissolving slowly when placed between the tongue and gums. Lozenges provide maximum amount of local action thus Chlorhexidine and Flubiprofen are formulated as lozenges to provide local antiseptic and anti-inflammatory action. The lozenges were prepared using mannitol as base. Hydroxy Propyl Methyl Cellulose K4M and Hydroxy Propyl Methyl Cellulose K15M are used as polymers. Saccharine is used as taste masking agent. These were prepared using wet granulation tablet technology. Some selected formulations were tested for drug excipient interactions subjecting to IR Spectral analysis. Formulated troches were evaluated for weight variation, crushing strength, friability, thickness, taste, dissolution time, and assay. Crushing strength of optimized troches was found between 8.5-9 kg/cm2. The Troches can provide an attractive alternative formulation in the alleviation of pain and Inflammation.

Keywords: Hydroxy Propyl Methyl Cellulose K15M are used as polymers.