Abstract

PREPARATION & EVALUATION OF AZITHROMYCINPHOSPHOLIPID BASED PHYTOSOME FOR ORAL DRUG DELIVERY

Kanav Kalaspuria*, Dr. Sarvesh Jain Malviya and Anupam Patyal

Abstract

In the present study, Azithromycin-phospholipid complex was developed and evaluated for its impact on solubility and bioavailability of Azithromycin. Azithromycin phospholipid complex was prepared by solvent evaporation method and characterized. FTIR revealed the disappearance of the characteristic peaks of Azithromycin in the complex, which can be due to weakening, removal or shielding by the phospholipid molecule. This phenomenon could be due to packing of Azithromycin in the hydrophobic cavity of phospholipid and being held by van der Waals forces and hydrophobic interactions. Azithromycin phospholipid complex exhibited increased solubility, dissolution rate with decreased distribution coefficient indicating its increased hydrophilicity. Oral bioavailability of Azithromycin and Azithromycin phospholipid complex were evaluated in Sprague-Dawley (SD) rats. Azithromycin-PLC exhibited considerable enhancement in the bioavailability with an increase in concentration maxima. This enhancement can be attributed to the improvement of the aqueous solubility of the complex and a probable decrease in its extent of intestinal and hepatic metabolism. Thus, phospholipid complexation holds a promising potential for increasing oral bioavailability of Azithromycin.

Keywords: Sustain release, In vitro release.