Abstract

SOLUBILITY ENHANCEMENT OF GLIPIZIDE USING SOLID DISPERSION TECHNIQUE

Hemant Rote*, V.M. Thakare, B.W. Tekade, R.P. Zope, R.Y. Chaudhari, V.R. Patil.

Abstract

Solubility is an important physicochemical factor affecting absorption of drug and its therapeutic effectiveness. The poor solubility of drug substances in water and their low dissolution rate in aqueous G.I.T fluid often leads to insufficient bioavailability. Glipizide is a poorly water soluble BCS Class-II drug having poor solubility. The purpose of present investigation was to enhance the solubility and bioavailability of poorly water soluble anti diabetic drug glipizide by formulating physical mixtures and solid dispersions (SDs) using spray drying technique with PVP K30 and PEG 6000 and with Skimmed Milk (SM) by kneading technique in ratios of 1:1 to 1:8. The prepared SDs were characterized by Differential scanning calorimetry (DSC), X-ray powder diffraction (XRD), Fourier transform infrared spectroscopy (FTIR) study, In vitro drug release study and UV interference method. The SDs prepared in this study exhibited better dissolution rates in comparison to physical mixtures and intact drug. It was found that the optimum weight ratio for drug: carrier is 1:8 in all cases. But with GZ: PEGSD5 the solubility enhancement was achieved to greater extent up to 90.70% in terms of Cumulative percent drug release and solubility of GZ was increased up to 7.15 folds.

Keywords: Glipizide, Spray drying Method, Kneading, Skimmed Milk, Polyvinyl Pyrrolidone (PVP K30), Polyethylene glycol (PEG 6000).