Abstract

PREPARATION AND SOLID-STATE ANALYSIS OF PIPERINE POLYMORPHS

Yetti Veena*, A. Anusha, E. Haseena, K. Praveena, K. Sunanda, K. Saidha Bhanu, N. V. Swapna and Y. Varalakshmi

Abstract

Pepper is a dietary phytochemical obtained from dried unripe fruit of „piper nigrum‟(black pepper) and piper longum belongs to the family of „piperaceae‟ pepper is a mixture of three geometrical isomers of piperine [chavicine, isochavicine] and capsaicin is the main pungent principle. The present study relates to the preparation of different solid forms of piperine. Polymer induced heteronucleation is a powerful crystalline polymorph discovery method has revealed the novel polymorphs of low solubility bio enhancer of piperine the existence polymorphs can enhance the solubility when compared to input material there by potentially increasing the efficacy of piperine as a bio enhancer. The piperine polymorphs are prepared by different methods like solvent evaporation, cooling crystallization, vapor diffusion method, gradual cooling method, slurry method, binary solvent mixture method, Antisolvent method. The developed polymorphs were characterized by various spectral methods like Fourier Transform Infrared Spectroscopy [FTIR] Powder X-ray diffraction [PXRD], Differential Scanning Colorimetry [DSC] and thus the polymorphic forms of piperine enhances the solubility of drug.

Keywords: (Piper nigrum, polymorph, crystallization, PXRD, DSC, FT-IR).