Abstract

FORMULATION AND EVALUATION OF VALSARTAN SUSTAINED RELEASE COMPRESSION COATED TABLETS

*T. Rajitha and K. Raju

Abstract

The present investigation was aimed to prepare Valsartan sustained release tablets compression coated using different concentrations of HPMC K4M, K15M, Ethyl cellulose and combination of Ethyl cellulose and HPMC K15M. The prepared Valsartan sustained release compression coated granules were subjected to pre-compression properties to comply with pharmacopoeial limits and the prepared tablets were characterized for weight variation, hardness, thickness, friability drug content, swelling studies and invitro dissolution studies. The in vitro drug release study F14 was the most successful formulation which includes both HPMC K15M and Ethyl cellulose, extended the drug release up to 12 h and exhibited satisfactory drug release in the initial hours. Mechanism of drug release was estimated by using different kinetic models like zero order, first order, Peppas and Higuchi‟s. The drug release from optimized formulation (F14) followed first-order kinetics via non-fickian (anomalous) diffusion.

Keywords: BP = British Pharmacopoeia Conc. = Concentration cps = Centipoises CC = Compression coated CRDDS = Controlled Release Drug Delivery System ?C = Degree Centigrade EC = Ethylcellulose FTIR = Fourier Transform Infrared Spectroscopy GIT = Gastrointestinal tra