Abstract

DETERMINATION OF EVALUATION PARAMETERS OF ETODOLAC COMPARED WITH STANDARD BY USING UVSPECTROPHOTOMETER

*Chintala Parimala Devi, Ameena A., Hemalatha B., Lakshmi Prasanna M., Latha Sree G., Sreelekha G. and Uma P.

Abstract

The present study deals with the comparison of validation parameters of marketed etodolac tablets (Etova 200mg) with API, by using UV spectroscopy. We are taken the absorbance ranges from 275-279.5 nm. Here we obey the Beer’s lamberts law for the calibration of UV. Here we used methanol and water in 9:1 ratio for validation of marketed formulation and API, hence this method is very accurate and simple and less time consuming. This method was validated in terms of results of analysis were validated statistically and recovery studies. From the above study we concluded that there was higher linearity to the marketed formulation when compared with API. Other than this there is no much variation in other validation parameters.

Keywords: Etodolac, UV, Linearity, Precision, Accuracy, Ruggedness, Robustness, LOD, LOQ, and Assay.