Abstract

MICROWAVE SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF NOVEL METAL-COMPLEXES WITH SCHIFF BASE DIETHYL 5- AMINO 4-METHYL THIOPHENE 3,5-DICARBOXYLATE-2,6- DIACETYLPYRIDINE

 Dr.Mohammed.Fakruddin Ali Ahamed.*, Dr.Venkatesan Jayakumar

Abstract

A series of some Schiff base complexes of Cu(II),Ni(II),Cr(II),Co(II), with a penta-dentateSchiff’s base Diethyl 5-amino 4-methyl thiophene 3,5-dicarboxylate -2,6- Diacetylpyridine(DAMT-DAP) has been synthesized under microwave conditions. The process is economical, easy, environment friendly and provides better yields of metal complexes in a shorter period of time. All the synthesized metal complexes and ligand were characterized on the basis of elemental analysis, 1H -NMR, IR and mass spectral data and study of antibacterial activity. The Schiff base and metal complexes displayed good activity against the Gram-positive bacteria Staphylococcus aureus, the Gram-negative bacteria Escherichia coli and the fungi Aspergillusniger and Candida albicans. The antimicrobial results also indicated that the metal complexes displayed better antimicrobial activity as compared to the Schiff bases.

Keywords: Microwave synthesis, green approach, antibacterial activity, penta-dentate Schiff’s base.