Abstract

DESIGN AND EVALUATION OF GASTRORETENTIVE FLOATING TABLETS OF DIURETIC FUROSEMIDE

Ayesha Naz*, Syeda Sadia, Mirza Askari Hussain Zama, Syeda Farheena Tarannum Shah, Ayesha Jabeen and Mohammed Abdul Salaam

Abstract

The present study concerns the development of gastroretentive floating tablets of diuretic drug Furosemide which release the drug in a sustained manner over a period of 12 h. Direct compression technology was employed for formulating the tablets. Various natural polymers like xanthan gum, carbopol and sodium alginate were used. In the present study furosemide floating tablets were prepared by effervescence method using sodium bicarbonate as a gas generating agent. Formulations were evaluated for weight variation, thickness, hardness, friability, content uniformity, swelling index, floating lag time and in vitro drug release. The dissolution studies was evident that the optimised formulation of sodium alginate showed better and desired drug release of 93% in 12 hrs. In vitro drug release pattern of furosemide floating tablets was fitted to different kinetic models which showed highest regression for zero order kinetics with non fickian diffusion mechanism.

Keywords: Gastroretentive tablet, Furosemide, xanthan gum, sodium alginate, Carbopol.