Abstract

A NEW DIRECTION TO COMBAT A GLOBAL PANDEMIC CORONA VIRUS DISEASE (COVID-19) BY A BROAD SPECTRUM PROTEASE INHIBITOR – ALPHA-2-MACROGLOBULIN (A2M)

*Mohammad Munir Hossain Khan MBBS, PhD

Abstract

Currently a pandemic, an emerging, rapidly evolving deadly respiratory disease killing thousands of people every day in the world caused by a novel coronavirus that was first reported from Wuhan, China, on 31 December 2019 and which has now been detected in more than 100 locations internationally, including in the United States. The virus has been named “SARS-CoV-2” and the disease it causes has been named “coronavirus disease 2019” (abbreviated “COVID-19”). World Health Organization (WHO) described aboutCOVID-19 on March 13, 2020 that “Coronaviruses (CoV) are a large family of viruses that cause illness ranging from the common cold to more severe diseases such as Middle East Respiratory Syndrome (MERS-CoV) and Severe Acute Respiratory Syndrome (SARS-CoV). A novel coronavirus (nCoV) is a new strain that has not been previously identified in humans. Coronaviruses are zoonotic, meaning they are transmitted between animals and people. Detailed investigations found that SARS-CoV was transmitted from civet cats to humans and MERS-CoV from dromedary camels to humans. Several known coronaviruses are circulating in animals that have not yet infected humans. According to the report from CNN (March 17, 2020): There is now a total of 173,334 reported cases of COVID-19 globally and 7019 deaths. In China reported 80,881 and death 3194. Most cases continue to be reported from Hubei province. Outside of China 61,518 confirmed 2199 deaths and 135 countries are affected.

Keywords: .