Abstract

PIPERINE: DELIGHTFUL SURPRISE TO THE BIOLOGICAL WORLD, MADE BY PLANT “PEPPER” AND A GREAT BIOAVAILABILITY ENHANCER FOR OUR DRUGS AND SUPPLEMENTS.

Mr. Vijay kumar Singh*, Preeti Singh, Ashutosh Mishra Anand Patel,Kamlesh KM Yadav

Abstract

Several of the common spices consumed as food adjuncts to impart flavour, aroma and colour to foods are also documented to exhibit several health beneficial physiological effects1. The beneficial physiological effects of the black pepper (Piper nigrum) are incidentally attributable to their active principles piperine (the biting principle of black pepper)1. Piperine is a major ingredient of black pepper and long pepper, which are widely used as a spice and in Ayurvedic medicine. Piperine {[1-5-(1, 3)-benzodioxol-5-yl)-1-oxo-2, 4-pentadienyl]-piperidine}, an alkaloid responsible for the pungency of black pepper & long pepper. Systemic pharmacological studies on piperine have revealed that this compound elicited diverse pharmacological activities; analgesic, anti-pyretic, anti-inflammatory, anti-convulsant & CNS-depressant activities. Piperine {[1-5-(1, 3)-benzodioxol-5-yl)-1-oxo-2, 4-pentadienyl]-piperidine},an alkaloid responsible for the pungency of black pepper & long pepper. Systemic pharmacological studies on piperine have revealed that this compound elicited diverse pharmacological activities; analgesic, anti-pyretic, anti-inflammatory, anti-convulsant & CNS-depressant activities. Black pepper is used not only in human dietaries but also for a variety of other purposes such as medicinal, as a preservative, and in perfumery. Many physiological effects of black pepper, its extracts, or its major active principle, piperine, have been reported in recent decades. Dietary piperine, by favorably stimulating the digestive enzymes of pancreas,enhances the digestive capacity and significantly reduces the gastrointestinal food transit time.

Keywords: Bioenhancer, Piperine,