Abstract

A COMPARATIVE STUDY ON QUALITY ANALYSIS ON MARKETED VITAMIN C (ASCORBIC ACID) CHEWABLE TABLETS OF DIFFERENT BRANDS AVAILABLE IN BANGLADESH

Md. Imran Hossain*, Sumaya Tanzin Wahid

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Abstract

Ascorbic acid is used to treat scurvy, delayed wound and bone healing, urine acidification, used as an antioxidant, and vitamin C deficiency. This study was involved to determine the physical and chemical parameters of different brand tablets of ascorbic acid chewable tablets in Bangladesh. The comparison among the products was done by using of the standard parameters of pharmacopeia specifications. Tablets used in this analysis was collected from the local market. Different popular brands were chosen for the study of different quality control tests involving appearance, hardness, friability, disintegration time, weight variation, dissolution rate & assay were calculated. The result of the hardness was shown between 3-20 kg/N. Friability results were also shown not more than 1 % which is matched with the USP specification for the all samples except Nutrivit C (1.151%). According to in-vitro dissolution of pharmacopeia, Ceevit (77.218%) dissolution profile didn’t match with the standard limit and the all other samples meet the acceptance criteria of pharmacopeia. Assay tests result meet the acceptance criteria for all brands. This study is an analysis of between the market products that gives the clear comparison between the products to give the information to the prescriber communities to have the great choice of medicines by choosing the best products among different brands.

Keywords: Ascorbic Acid, Vitamin C, Pharmacopeia, Dissolution rate, Assay.