Abstract

A REVIEW ON VALIDATED RP-HPLC METHOD FOR SIMULTANEOUS ESTIMATION OF EMTRICITABINE AND TENOFOVIR DISOPROXIL FUMARATE IN A TABLET DOSAGE FORM

Vrushali N. Desai*, Nachiket S. Dighe and Amol S. Dighe

Abstract

Tenofovir Disoproxil Fumarate and Emtricitabine are successfully utilized in the avoidance of HIV-1 contaminations. They are for the most part managed as tablets. These are Nucleotide Reverse Transcriptase Inhibitors (NtRTIs), a non-cyclic nucleoside phosphonate (nucleotide) simple of adenosine 5′-monophosphate. Emtricitabine and Tenofovir disoproxil fumarate uncovers similarly avoidance of the chemical that is HIV-1 turn around transcriptase. For assurance of Tenofovir disoproxil fumarate and Emtricitabine in mass and pharmaceutical measurement structure, a few investigative strategies including UV, HPLC, UPLC, and HPTLC procedures are accounted for in writing. For subjective and quantitative estimation of Tenofovir disoproxil fumarate and Emtricitabine these diagnostic techniques can be utilized and furthermore for the related degradants in mass definitions and natural liquid. The present paper outlines the audit on systematic techniques which includes the estimation of the antiviral drugs.

Keywords: Emtricitabine, Tenofovir disoproxil fumarate, RP-HPLC, UPLC.