Abstract

SPHERICAL AGGLOMERATION TECHNIQUE: A INNOVATIVE ENGINEERING PERSPECTIVE FOR IMPROVEMENT OF MICROMERITIC PROPERTIES OF DRUGS

*Umesh R. Dhas, Meghana S. Bhadarge, Abhay R. Shirode

Abstract

Direct compression of powder is very simplest and easiest way of manufacturing tablets. good flow ability and compressibility plays a major role for direct compression of drugs there are several techniques available to impart desired compressibility to drugs. Spherical agglomeration technique are reliable technique in which the drug crystals are modified using different solvents to directly compressible spherical agglomerates, which less economical and time saving. The article gives a detailed review and focused on desired outcomes, trouble shooting/ possible formulation challenges and limitation of techniques, process variable, method of preparation along with the evaluation and characterization of agglomerates, and also focused on solvent used by researchers for preparation of spherical agglomerates of different drugs and improved micrometric properties.

Keywords: Compressibility, flow property, direct compression, spherical agglomeration, formulation challenges.