Abstract

NOVEL RESEARCH STRATEGIES OF SULFONAMIDE DERIVATIVES

*Payal Agrawal, Priyanka Chaturvedi and Surendra Jain

Abstract

Sulfonamide plays a vital role in medicinal chemistry which is used as an antimicrobial, diuretic, oral hypoglycaemic agent for discovery of novel therapeutic agents. Substitution of sulfonamide nucleus is a significant synthetic strategy in drug discovery process. Therapeutic properties of sulfonamides related drugs have motivated the medicinal chemists to synthesize novel therapeutic agents. In this review, sulfonamide derivatives with different pharmacological activities are reported on the basis of substitutions on the nucleus with an aim to help medicinal chemists for the development of SAR on sulfonamides for each activity. This article main object is to review the work done, chemistry and pharmacological activities of sulfonamide derivatives during past years. Clinical treatment with sulfonamides has regained confidence with the use of a combination of sulfamethoxazole and trimethoprim to treat urinary tract bacterial infections. Today, they are widely used as antimicrobial agents, chiefly because of their low cost, low toxicity and excellent activity against bacterial diseases.

Keywords: Sulfonamides, pharmacological activities, novel therapeutic agents etc.