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WJPR

World Journal of Pharmaceutical Research

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology

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Abstract

EVALUATION OF ANTIDIARRHOEAL ACTIVITY OF ETHANOLIC EXTRACT OF PTERIDIUM AQUILINUM (L.) KUHN LEAVES ON ALBINO RATS

A. T. Toby, O. T. Umoh*, V. E. Uyoh and O. M. Umoden

Abstract

The Phytochemical screening and the effect of ethanolic leaf extract of Pteridium aquilinum (L.) Kuhn. on castor oil induced diarrhoea in albino rats were studied. The doses of the extract administered were 245, 490 and 735mg/kg, respectively. The result indicated that there was a non-dose dependent decrease in the number of P. aquilinum that has antidiarrhoeal properties. The result of the phytochemical screening of the leaf extract reveals the presence of tannins, phlobatannins, saponins, terpenes, cardiac glycosides, alkaloid and anthraquinones. The lethal dose of 50% level (LD50) was established to be 2449.49mg/kg.

Keywords: Antidiarrhoeal, Diarrhoea, Phytochemicals, Pteridium.

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