Abstract

DESIGN, CHARACTERIZATION AND EVALUATION OF MUCOADHESIVE COLON TARGETED DRUG DELIVERY SYSTEM FOR PREDNISOLONE

Dr. S. Chandra*, S. Sangeetha, S. Mary Julian Benedict, R. Suresh, B. Nandhini and A. Sheik Alisha

Abstract

Evaluation of colon targeted drug delivery of anti-inflammatory drug y Mucoadhesive bilayer tablets containing prednisolone were prepared by Wet Granulation method. Various batches were prepared by changing the ratio of pectin, PVP K 30 to identify the most effective formulation CP-934 (mucoadhesive polymers), lactose (diluents), in a F1 – F2 After compression given by coating Eudragit polymer. each coated tablet containing 300mg of drugs, Drug polymer interaction was investigated by using FTIR. The preformulation studies and post compression studies are performed like mucoadhesive strength, determination of residence time in invitro dissolution study at pH 6.8 F6 shows maximum drug release at after 9hrs.

Keywords: PVP K 30, Eudragit, Mucoadhesive bilayer tablets.