Abstract

A COMPARATIVE STUDY BETWEEN DEXMEDETOMIDINE AND DEXMEDETOMIDINE PLUS FENTANYL AS PREMEDICATION FOR ATTENUATION OF HAEMODYNAMIC RESPONCES DURING LARYNGOSCOPY AND INTUBATION

Dr. Imran, Dr. Saikat Majumdar*, Dr. Soma Chakraborty, Dr. Chhandasi Naskar, Dr. Tusar Kanti Saha and Dr. Tanwee

Abstract

Introduction- Endotrachial intubation results untowards response in cardiorepiratory system causing poor outcome. Aims and Objectives – To compare effect of dexmeditomidine and dexmeditomidine plus fentanyl for attenuation of haemodynamic response. Methods- Total 100 patients equally divided in two groups, 50 each in this randomized double blinded study. Group-D received infusion dexmeditomidine 1μg/kg over 10 minutes, Group-DF received infusion dexmeditomidine 1μg/kg over 10 minutes plus fentanyl 2μg/kg given 3 minutes before induction. Both the groups received same anaesthesia protocol. Results- Decrease of HR 13.60% in DF group & 13.33% in D group (p>0.05). MAP decrease 6.66% in Group-D & 9.42% in Group-DF from base line. Increase in MAP is less in DF group. 11 patients showed bradicardia, 13 patients showed hypotension. None showed PONV & ECG abnormality. Conclusion- Dexmeditomidine plus fentanyl provide beneficial effect in attenuation of pressure response during intubation.

Keywords: Dexmeditomidine, fentanyl, attenuation, intubation.