Abstract

ACUTE ORAL TOXICITY STUDY OF ROOTS OF DRUG SHODHITA VATSANABHA (ACONITUM SPICATUM)

Ashwija N.H.*, Ravikrishna S., Sudhakar Bhat and Chaitrhra S. Hebbar

Abstract

Vatsanabha is a potent toxic drug explained by Bruhat trayees, and they have considered it under Mahavisha(Potent toxin). Acharya Sushruta mentioned it under Moola visha(Poisonous roots). It is considered to be potent cardiac poison used for homicidal or suicidal purpose. In this present study acute oral toxicity of drug Vatsanabha after the Shodhana (Purifactor method) has been carried out. Acharyas have explained various methods for Shodhana, and thereby used it in much Ayurvedic formulation. Purification procedure was carried out with Gomutra(Cow’s Urine) for 3 days. The present study was done on Wistar albino rats. After the Shodhana of drug Vatsanabha, albino rats were subjected to oral toxicity study. There was a decrease in central nervous activity, and later rats were died due to respiratory failure. It’s very significant to know the LD 50 drug Shodhita Vatsanabha since it is used in various ayurvedic formulations.

Keywords: Shodhana, Shodhita Vatsanabha, acute toxicity, experimental animals.