Abstract

EFFECT OF ETHANOLIC ROOT EXTRACT OF APOROSA LINDLEYANA ON LIPID PEROXIDATION, ENZYMATIC STATUS OF INH-RIF INDUCED TOXICITY ON MALE ALBINO WISTAR RATS

Ramakrishnan S.* and Venkataraman R.

Abstract

In this present study aimed to explore the hepato and renal protective effect of Ethanolic Root Extract of Aporosa lindleyana (EREAL) on INH-RIF induced toxicity on rats. INH-RIF administered rats showed increased oxidative stress not only by increasing the lipid peroxidation but also by decreasing the antioxidant capacity in plasma, tissues of liver and kidney. Administration of EREAL effectively controlled the lipid peroxidation process in INH-RIF rats, which were manifested by the decreased levels of lipid peroxidative markers such as Thiobarbituric acid reactive substances (TBARS) and lipid hydroperoxides in the plasma and tissues. EREAL also improved the antioxidant status of INH-RIF rats by increasing the activities of superoxide dismutase(SOD), catalase(CAT) and glutathione peroxidise(GPx).

Keywords: EREAL, INH-RIF, Lipid peroxidation, SOD, CAT, GPx.