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Abstract

FORMULATION AND EVALUATION OF KETOROLAC TROMETHAMINE OPHTHALMIC SOLUTION USING DIFFERENT CONCENTRATIONS OF BENZALKONIUM CHLORIDE

Dr. S. Chandra*, S. Sangeetha, P. Anilkumar, B. Nandhini, R. Suresh, S. Kavi Bharathi

Abstract

Formulation of Ketorolac tromethamine ophthalmic solution containing different concentration of benzalkonium chloride in(F1-F3) Disodium EDTA Sodium chloride, Octoxynol 40, Sodium hydroxide, Water for injection are used in our preparation Hcl to adjust the pH in quantity sufficient, ophthalmic solution is prepared by simple solution method post formulation studies are performed Drop size, Bacterial Endo toxin Test, Sterility Test and antimicrobial studies perfomed by bacteria P.aeruginosa,S. aureus, E. coli, and Fungi (Yeast/ Mold):(C. albicans, A.brasiliensisare used and stability study taken for 3months, The physical appearance and the assay (% drug release)shows results as 100.5% for ketorolac tromethamine and 99.8% for BKC.

Keywords: EDTA, BKC, Sodium hydroxide, ophthalmic solution.


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