Abstract

COMPARATIVE STUDY OF PHARMACOLOGICAL EFFICIENCY OF MARINE SPONGES

Raishy R. Husssain Ph. D.*, Noha Laj Ph. D. and V. Aldous J. Huxley PhD

Abstract

Background: Pharmacological evaluation of sponge extracts was carried out through the screening of analgesic activity, anticonvulsant activity, neurotoxicity studies, anti- inflammatory activity, diuretic strength and antioxidant activity of experimented animals after administration of specific sponge extracts. Materials and methods: To compare the pharmacological efficacy studies, five potent sponges were selected such as Haliclona. exigua, Axinella. donnani, Callyspongia, Sigmadocia and Dendrilla. nigra. Animal models were selected for the successful pharmacological screening of sponge extracts. Albino mice from Kings Institute, Guindy were used as the animal model throughout the screening studies. The lethal dose of sponge extracts determined prior to pharmacological evaluation. The toxicity studies were carried as per OECD guidelines 423. Results: By neurotoxic evaluation of five selected sponge extracts, H. exigua exhibit effective neurotoxic potency. Of the five sponge extracts administered mice groups, H. exigua extracts received groups showed in effect analgesic action. By equating five sponge extracts, H. exigua extracts administered mice group exhibited potent anticonvulsant action similar to reference drug, Diazepam in all three screening methods. H. exigua extracts and control drug, diclofenac sodium administered mice groups exhibited more antiinflammatory efficacy than other sponge extracts administered mice group. H. exigua administered mice group produced effective diuretic potential resemble diuretic drug administered mice groups. Amongst five sponge extracts, H. exigua administered mice group produced a profound effect on antioxidant activity. Conclusion: The above pharmacological screening output clearly indicated that H.exigua extracts exhibited more potent in all aspects. The pharmacological potential of H.exigua revealed the presence of an active ingredient in the current drug development strategy.

Keywords: Pharmacological efficacy, marine sponges.